The ABCDE rule is a dermatologist-developed mnemonic for identifying moles that warrant professional evaluation. It stands for Asymmetry, Border, Color, Diameter, and Evolution. Use this interactive guide to understand each criterion, apply it to your own moles, and determine if a dermatologist visit is warranted.

Medical disclaimer: This is an educational guide only. It cannot diagnose skin cancer. Only a licensed dermatologist can provide a proper evaluation. See a dermatologist immediately for any rapidly changing or bleeding mole.
A

Asymmetry

Draw an imaginary line through the center of the mole. In a benign (normal) mole, both halves match. In a potentially concerning mole, the two halves look different.

Normal: Symmetric
Concerning: Asymmetric
B

Border

Benign moles have smooth, well-defined borders. Concerning moles may have ragged, notched, blurred, or irregular edges that fade into surrounding skin.

Normal: Smooth border
Concerning: Irregular
C

Color

Benign moles are typically a single shade of tan or brown. Concerning moles may show multiple shades of brown, black, red, white, or blue within the same lesion.

Normal: Uniform color
Concerning: Color variation
Watch for: Light brown Dark brown/black Red White/depigmented Blue-black
D

Diameter

Most melanomas are larger than 6mm (about the size of a pencil eraser) when diagnosed. However, melanomas can be smaller when caught early — size alone is not definitive.

Normal: <6mm
Concerning: >6mm
6mm ≈ pencil eraser tip
E

Evolution

Evolution is often considered the most critical criterion. Any mole that changes over weeks to months — in size, shape, color, or texture — deserves prompt professional evaluation.

Signs of concerning evolution:

  • Increasing in size over weeks or months
  • Changing color or developing new shades
  • Changing shape or developing irregular edges
  • Bleeding without injury
  • Itching, crusting, or becoming painful
  • New mole appearing in adulthood (especially after 50)

Additional Risk Factors to Discuss With Your Dermatologist

Personal or family history of melanoma
Fair skin, light hair, light eyes
History of blistering sunburns, especially in childhood
More than 50 moles (or any atypical moles)
History of tanning bed use
Immunosuppression (transplant medications, HIV, chemotherapy)